FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival
نویسندگان
چکیده
منابع مشابه
Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats
Objective(s): Skin flap necrosis is the most common postoperative side effect in reconstructive surgeries. Glutamine (GLN) has been shown to accelerate wound healing process. The purpose of this study was to evaluate the effects of GLN either in free form or in the dipeptide form along with L- alanyl (Ala-GLN) on random skin flaps survival in rats.Materials and Methods: Dorsal skin flaps with c...
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Autophagy is a cytoprotective process, which occurs following temozolomide (TMZ) treatment, and contributes to glioma chemoresistance and TMZ treatment failure. However, the molecular mechanisms by which TMZ induces autophagy are largely unknown. In the current study, the ataxia‑telangiectasia mutated (ATM) inhibitor KU‑55933, adenosine monophosphate‑activated protein kinase (AMPK) inhibitor co...
متن کاملThe Effects of Polydeoxyribonucleotide on the Survival of Random Pattern Skin Flaps in Rats
BACKGROUND Partial or complete necrosis of a skin flap is a common problem. Polydeoxyribonucleotide (PDRN) can be extracted from trout sperm and used as a tissue repair agent. The aim of this study was to investigate whether PDRN could improve the survival of random pattern skin flaps in rats. METHODS Twenty-two male Sprague-Dawley rats were randomly divided into two groups: the PDRN treatmen...
متن کاملThe effect of Arnebia purpurea extract on the survival of random pattern skin flaps in rats
Objectives. One of the important causes of flap losses is ischemia-reperfusion damage. Arnebia species are rich in naphthoquinone derivatives which known to have anti-inflammatory and anti-oxidant effects. The aim of the present study was to investigate the effects of Arnebia purpurea extract on viability of the skin flaps. Methods. Eighteen Wistar rats were divided in three groups. Caudal-base...
متن کاملIsoflurane preconditioning increases survival of rat skin random-pattern flaps by induction of HIF-1α expression.
BACKGROUND Survival of random-pattern skin flaps is important for the success of plastic and reconstructive surgeries. This study investigates isoflurane-induced protection against ischemia of skin flap and the underlying molecular mechanism in this process. METHODS Human umbilical vein endothelial cells (HUVECs) and human skin fibroblast cells were exposed to isoflurane for 4 h. Expression o...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2019
ISSN: 2041-4889
DOI: 10.1038/s41419-019-2105-0